Tetsuaki Arai Selected Research

Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)

1/2022	The Diagnostic Patterns of Referring Physicians and Hospital Expert Psychiatrists Regarding Particular Frontotemporal Lobar Degeneration Clinical and Neuropathological Subtypes.
1/2021	Distinct early symptoms in neuropathologically proven frontotemporal lobar degeneration.
10/2020	Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.
11/2019	The basis of clinicopathological heterogeneity in TDP-43 proteinopathy.
7/2018	Clinical features of the behavioural variant of frontotemporal dementia that are useful for predicting underlying pathological subtypes of frontotemporal lobar degeneration.
6/2018	Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.
2/2018	Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.
1/2018	Fluorescence in-situ hybridization method reveals that carboxyl-terminal fragments of transactive response DNA-binding protein-43 truncated at the amino acid residue 218 reduce poly(A)+ RNA expression.
1/2017	Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.
10/2016	Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation.

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Tetsuaki Arai Research Topics

Disease

44	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2022 - 12/2006
30	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2020 - 07/2002
20	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 05/2003
13	Frontotemporal Dementia (Semantic Dementia) 01/2022 - 05/2003
11	Dementia (Dementias) 01/2022 - 01/2004
11	TDP-43 Proteinopathies 10/2020 - 11/2008
8	Cognitive Dysfunction 07/2022 - 01/2019
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2006
6	Tauopathies 01/2022 - 01/2003
6	Sarcoma (Soft Tissue Sarcoma) 01/2022 - 01/2010
5	Atrophy 01/2021 - 07/2005
4	Corticobasal Degeneration 01/2022 - 05/2003
4	Synucleinopathies 01/2018 - 10/2007
3	Pick Disease of the Brain (Pick's Disease) 01/2022 - 05/2003
3	Major Depressive Disorder (Major Depressive Disorders) 01/2019 - 09/2006
3	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 09/2009 - 05/2003
3	Parkinsonian Disorders (Parkinsonism) 12/2008 - 01/2006
2	COVID-19 01/2022 - 01/2020
2	Schizophrenia (Dementia Praecox) 09/2021 - 02/2012
2	Proteostasis Deficiencies 01/2017 - 11/2012
2	Diffuse Neurofibrillary Tangles with Calcification 02/2011 - 07/2005
2	Amyloid Plaque 02/2011 - 01/2006
2	Lewy Body Disease (Lewy Body Dementia) 12/2010 - 10/2007
2	Multiple System Atrophy 09/2009 - 10/2007
2	Huntington Disease (Huntington's Disease) 09/2009 - 12/2008
2	Parkinson Disease (Parkinson's Disease) 09/2009 - 10/2006
2	Neuroblastoma 10/2006 - 01/2006
1	Trauma and Stressor Related Disorders 09/2022
1	Infections 01/2022
1	Emotional Exhaustion 01/2022
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Stroke (Strokes) 11/2019
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2018
1	Snoring 01/2018
1	Disease Progression 02/2011
1	Parasitic Diseases (Parasitic Disease) 01/2011
1	Delirium 02/2010
1	Diarrhea 02/2010
1	Progressive Multifocal Leukoencephalopathy 12/2009
1	Leukocytosis (Pleocytosis) 12/2008
1	Postmortem Changes (Adipocere) 08/2008

Drug/Important Bio-Agent (IBA)

31	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022 - 12/2006
26	UbiquitinIBA 11/2019 - 07/2002
19	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2004
9	sarkosylIBA 01/2022 - 10/2007
8	AntibodiesIBA 10/2010 - 01/2006
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 07/2009
5	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2004
5	ProgranulinsIBA 02/2018 - 11/2008
4	Biological ProductsIBA 09/2022 - 09/2006
4	TabletsIBA 01/2022 - 01/2019
4	PrionsIBA 01/2022 - 01/2012
4	Amyloid beta-PeptidesIBA 01/2022 - 01/2004
4	SynucleinsIBA 11/2019 - 12/2010
4	Pharmaceutical PreparationsIBA 11/2019 - 01/2011
4	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2010 - 05/2003
3	Protein Isoforms (Isoforms)IBA 01/2022 - 11/2008
3	GranulinsIBA 02/2018 - 02/2015
2	DNA (Deoxyribonucleic Acid)IBA 12/2014 - 12/2008
2	Methylene Blue (Methylthioninium Chloride)FDA Link 01/2012 - 07/2009
2	4- N,N- dimethylamino- 1- naphthylisothiocyanateIBA 02/2011 - 07/2005
2	Valosin Containing ProteinIBA 01/2010 - 11/2008
2	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 11/2009 - 10/2007
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 10/2006 - 01/2006
2	Messenger RNA (mRNA)IBA 10/2006 - 01/2006
2	Thrombin FDA Link 01/2006 - 02/2005
1	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA 01/2022
1	blonanserinIBA 09/2021
1	Ataxin-2IBA 10/2020
1	DiamondIBA 01/2020
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 05/2019
1	Rivastigmine (Exelon)FDA LinkGeneric 05/2019
1	Iodine-123IBA 11/2018
1	Protein AggregatesIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Detergents (Detergent)IBA 01/2018
1	TrypsinIBA 02/2016
1	RNA Polymerase II (RNA Polymerase B)IBA 08/2014
1	Presenilin-1IBA 01/2014
1	p38 Mitogen-Activated Protein KinasesIBA 03/2011
1	Cadherins (E-Cadherin)IBA 03/2011
1	Superoxide Dismutase-1IBA 01/2011
1	Peptide Hydrolases (Proteases)FDA Link 11/2010
1	Thiamine (Aneurin)FDA Link 02/2010
1	Green Fluorescent ProteinsIBA 09/2009
1	AD 5IBA 09/2009
1	latrepirdine (dimebon)IBA 07/2009
1	AcidsIBA 07/2009
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2009
1	Coloring Agents (Dyes)IBA 08/2008
1	Urea (Carbamide)FDA LinkGeneric 08/2008
1	PhosphopeptidesIBA 07/2008
1	Casein Kinase II (Casein Kinase 2)IBA 10/2007
1	EnzymesIBA 10/2007

Therapy/Procedure

7	Therapeutics 11/2019 - 01/2010
2	Medical Day Care (Partial Hospitalization) 07/2022 - 01/2022
2	Transdermal Patch 09/2021 - 05/2019
1	Treatment Delay 01/2022
1	Home Nursing (Nursing, Home) 01/2022
1	Injections 04/2013